Vol 1-1 Mini Review

Improving Adherence to Reach Out and Read: A Bookmark Intervention

Elsia A. Obus1, Natalie H. Brito2, Lauren Sanlorenzo2, Corinna Rea2, Laura Engelhardt2, Kimberly G. Noble1*

1Teachers College, Columbia University, USA
2Columbia University Medical Center, USA

This study examines how the addition of a modest addendum to the well-established pediatric primary care program, Reach Out and Read (ROR), is associated with increased clinician adherence to ROR and caregiver home literacy behavior. This study took place in four ambulatory care clinics at a large urban medical center. All clinics received standard ROR training. Two of the four clinics received additional ROR training and bookmarks with age-specific advice about reading aloud with children. Following the intervention, medical providers reported no behavioral differences, however caregivers in the intervention group reported: more frequent trips to the library, receiving more books from their pediatrician, and receiving more advice on how to read with their child than caregivers in from the comparison clinics. Thus the addition of a modest training and bookmark intervention to the ROR program was associated with caregiver report of both increased clinician adherence to ROR and increased caregiver literacy behavior. The bookmark intervention may be an inexpensive way to improve the effects of the ROR program.

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Vol 1-1 Commentary

Commentary: Adaptive from innate: Human IFN-?+ CD4+ T cells can arise directly from CXCL8-producing recent thymic emigrants in babies and adults

Deena L. Gibbons1* and Paul Fleming2

1Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, Kings College London
2Department of Neonatology, Homerton University Hospital NHS Foundation Trust, London

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Vol 1-1 Commentary

Commentary: Association of autoimmune hepatitis and Evans syndrome in children

Chaowapong Jarasvaraparn1, David A. Gremse2*

1Department of Pediatrics, University of South Alabama, Mobile, Alabama 36604, USA

2Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of South Alabama, Mobile, Alabama 36604, USA

Autoimmune hepatitis (AIH) is a chronic liver disease that may be associated with extrahepatic autoimmune disorders. Evans syndrome (ES) is an autoimmune disorder that is characterized by a combination of immune thrombocytopenia and autoimmune hemolytic anemia. Association of autoimmune hepatitis with Evans syndrome is rare, especially in children. We reported a 3-year-old-female with pre-existing Evans syndrome who developed AIH type 11This commentary reviews this case along with other reported cases of AIH and ES.

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Vol 1-1 Mini Review

A helper virus-independent, plasmid only-based reverse genetics system for rotavirus

Ulrich Desselberger

Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge, U.K.

Compared to classical ‘forward’ genetics in which the changed phenotype of an organism is correlated with mutations in the genome, the availability of complete nucleotide sequences of many microbes and animals now allows the rational engineering of mutations in individual genes and identification of the correlated change in phenotype of the reconstituted organism (‘reverse genetics’). Reverse genetics enables precise assignment of phenotypic changes to genomic mutations. The goal to ‘rescue’ infectious rotavirus from a mutated genome has eluded success for a long time, and only recently a plasmid only-based, helper virus-free reverse genetics system for species A rotaviruses has been developed. Based on background information on rotavirus structure, classification, replication and genetic research, the new procedure is reviewed in detail, and its versatility and significance for future basic and translational research are discussed.

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Vol 1-1 Commentary

Is it important to investigate the clinical periodontal and microbiological condition in juvenile idiopathic arthritis patients (JIA)?

Consuelo Romero- Sánchez1,2*

1Pediatric Rheumatology Program, School of Medicine, Unit of Oral Basic Investigation, School of Dentistry, Universidad El Bosque, Bogota, Colombia
2Group of Applied Clinical Immunology, Rheumatology and Immunology Department Hospital Militar Central, School of Medicine, Universidad Militar Nueva Granada, Bogota, Colombia.

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